Bone Morphogenetic Proteins and Growth Factors: Emerging Role in Regenerative Orthopaedic

Dr. Gholipour

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Iran Veterinary Intern-Resident
Bone Morphogenetic Proteins and Growth Factors: Emerging Role in Regenerative Orthopaedic Surgery

P. De Biase & R. Capanna


Pages: 6
Publisher: Journal of Orthopaedics and TraumatologyLanguage: English
Edition: No. 8, P. 43–48



Description:

Bone morphogenetic proteins (BMPs) were discovered by Urist and colleagues in 1965 and later defined as multifunctional cytokines involved in osteoinduction. BMPs are members of the transforming growth factor-β superfamily, with the exception of the BMP-1. Presently, at least 20 BMPs have been identified and studied, but only BMP 2, 4 and 7 have been able in vitro to stimulate the entire process of stem cell differentiation into osteoblastic mature cells.


 
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