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Insulin-Induced Laminitis - An investigation of the disease mechanism in horses
82 pagesPublished: 19 Dec 2011
Author(s): Melody de Laat, Martin Sillence, Catherine McGowan, Christopher Pollitt
ISBN: 978-1-74254-295-9
This project has demonstrated that insulin-sensitive horses, in addition to ponies, develop laminitis experimentally if high concentrations of insulin circulate in their bloodstream for 48 hours. This discovery shifts the focus of endocrinopathic laminitis pathogenesis away from insulin resistance and hypercortisolaemia towards insulin itself having a direct laminitogenic affect. The research has discounted pathogenic roles for digital vasodilation, lamellar metalloproteinase activity and inflammation in the development of this form of laminitis. The major outcome from this project is that hyperinsulinaemia triggers uncontrolled lamellar cell proliferation and attenuation. This process weakens the lamellar suspensory apparatus of the distal phalanx until the clinical signs of foot pain are manifest. This new, alternative theory for the pathogenesis of insulin-induced laminitis maintains Australia’s leadership in equine laminitis research.
The horse breeding and sporting industries, equine veterinary industry and farriery associations across all regions of Australia can potentially benefit from the data contained in this report.
82 pagesPublished: 19 Dec 2011
Author(s): Melody de Laat, Martin Sillence, Catherine McGowan, Christopher Pollitt
ISBN: 978-1-74254-295-9
This project has demonstrated that insulin-sensitive horses, in addition to ponies, develop laminitis experimentally if high concentrations of insulin circulate in their bloodstream for 48 hours. This discovery shifts the focus of endocrinopathic laminitis pathogenesis away from insulin resistance and hypercortisolaemia towards insulin itself having a direct laminitogenic affect. The research has discounted pathogenic roles for digital vasodilation, lamellar metalloproteinase activity and inflammation in the development of this form of laminitis. The major outcome from this project is that hyperinsulinaemia triggers uncontrolled lamellar cell proliferation and attenuation. This process weakens the lamellar suspensory apparatus of the distal phalanx until the clinical signs of foot pain are manifest. This new, alternative theory for the pathogenesis of insulin-induced laminitis maintains Australia’s leadership in equine laminitis research.
The horse breeding and sporting industries, equine veterinary industry and farriery associations across all regions of Australia can potentially benefit from the data contained in this report.