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Prions and Diseases, Volume 1, Physiology and Pathophysiology
by Wen-Quan Zou
Pages: 317
Publisher: --
Edition: 1st., 2013
Language: English
ISBN: 978-1461453048
Description
Transmissible spongiform encephalopathies (TSE), now broadly known as prion diseases, have been recognized for nearly 300 years in animals and almost 100 years in humans. However, the nature of the transmissible agent had largely remained a mystery until Stanley Prusiner discovered the infectious isoform of the prion protein (PrP), named prion or scrapie PrP (PrP[SUP]Sc[/SUP]), in 1982. The subsequent modern studies with protein chemistry and molecular biology in cell culture, transgenic animals, and cell-free systems, including the revolutionary protein-misfolding cyclic amplification (PMCA), have greatly advanced our understanding of the pathogenesis of prion diseases and facilitated the identification of new prion diseases in animals and humans. In Prions and Prion Diseases, more than 60 leading researchers and clinicians worldwide provide an up-to-date development in many aspects of these unique infectious pathogens and their associated diseases.
Volume I highlights the association of the cellular prion protein (PrP[SUP]C[/SUP]) with copper and zinc, the potential roles of PrP[SUP]C[/SUP] in Alzheimer’s disease and cancers, insoluble PrP[SUP]C[/SUP], PMCA, molecular and cellular mechanisms of PrP[SUP]Sc[/SUP] formation and clearance, possible co-factors involved in the conversion of PrP[SUP]C[/SUP] into PrP[SUP]Sc[/SUP], infectious and pathogenic forms of PrP, cell biology of prions, prion strains and their interference, as well as yeast prions and their inheritable and structural traits. This unique volume covers history from the high Middle Ages to the TSE era of Daniel Carleton Gajdusek, followed by the prion era of Stanley Prusiner whose extraordinary discovery opened a new chapter in prion research. Volume I will take you through the fascinating chronicle of prions in mammals, yeast, and fungi.
Thread Related, Volume 2
by Wen-Quan Zou
Pages: 317
Publisher: --
Edition: 1st., 2013
Language: English
ISBN: 978-1461453048
Description
Transmissible spongiform encephalopathies (TSE), now broadly known as prion diseases, have been recognized for nearly 300 years in animals and almost 100 years in humans. However, the nature of the transmissible agent had largely remained a mystery until Stanley Prusiner discovered the infectious isoform of the prion protein (PrP), named prion or scrapie PrP (PrP[SUP]Sc[/SUP]), in 1982. The subsequent modern studies with protein chemistry and molecular biology in cell culture, transgenic animals, and cell-free systems, including the revolutionary protein-misfolding cyclic amplification (PMCA), have greatly advanced our understanding of the pathogenesis of prion diseases and facilitated the identification of new prion diseases in animals and humans. In Prions and Prion Diseases, more than 60 leading researchers and clinicians worldwide provide an up-to-date development in many aspects of these unique infectious pathogens and their associated diseases.
Volume I highlights the association of the cellular prion protein (PrP[SUP]C[/SUP]) with copper and zinc, the potential roles of PrP[SUP]C[/SUP] in Alzheimer’s disease and cancers, insoluble PrP[SUP]C[/SUP], PMCA, molecular and cellular mechanisms of PrP[SUP]Sc[/SUP] formation and clearance, possible co-factors involved in the conversion of PrP[SUP]C[/SUP] into PrP[SUP]Sc[/SUP], infectious and pathogenic forms of PrP, cell biology of prions, prion strains and their interference, as well as yeast prions and their inheritable and structural traits. This unique volume covers history from the high Middle Ages to the TSE era of Daniel Carleton Gajdusek, followed by the prion era of Stanley Prusiner whose extraordinary discovery opened a new chapter in prion research. Volume I will take you through the fascinating chronicle of prions in mammals, yeast, and fungi.
Thread Related, Volume 2
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