Guillermo Rodriguez
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Serotonin: a review
L. F. MOHAMMAD-ZADEH*
L. MOSES &
S. M. GWALTNEY-BRANT
J. vet. Pharmacol. Therap. 31, 187–199
5-Hydroxytryptamine, or serotonin, is a biogenic amine most noted for its role
as a neurotransmitter. Manipulation of serotonin in animal models was used as
a tool for studying its role in humans. Through such research serotonin has
been shown to modulate gastrointestinal motility, peripheral vascular tone,
cerebral vascular tone, and platelet function and has been implicated in the
pathophysiology of mood disorders, emesis, migraine, irritable bowel syndrome
(IBS), and pulmonary and systemic hypertension. The knowledge gained is
being directly applied back to animals in research on drugs that manipulate the
serotonergic system in dogs and cats. Increasing use and availability of drugs
that manipulate the serotonergic system has created a circumstance through
which a novel toxicity was discovered in both humans and animals. Serotonin
Syndrome describes the clinical picture seen in humans and animals with
serotonin toxicity. This paper provides a review the physiology of serotonin and
its involvement in the pathophysiologic mechanisms of various conditions,
including the Serotonin Syndrome.
L. F. MOHAMMAD-ZADEH*
L. MOSES &
S. M. GWALTNEY-BRANT
J. vet. Pharmacol. Therap. 31, 187–199
5-Hydroxytryptamine, or serotonin, is a biogenic amine most noted for its role
as a neurotransmitter. Manipulation of serotonin in animal models was used as
a tool for studying its role in humans. Through such research serotonin has
been shown to modulate gastrointestinal motility, peripheral vascular tone,
cerebral vascular tone, and platelet function and has been implicated in the
pathophysiology of mood disorders, emesis, migraine, irritable bowel syndrome
(IBS), and pulmonary and systemic hypertension. The knowledge gained is
being directly applied back to animals in research on drugs that manipulate the
serotonergic system in dogs and cats. Increasing use and availability of drugs
that manipulate the serotonergic system has created a circumstance through
which a novel toxicity was discovered in both humans and animals. Serotonin
Syndrome describes the clinical picture seen in humans and animals with
serotonin toxicity. This paper provides a review the physiology of serotonin and
its involvement in the pathophysiologic mechanisms of various conditions,
including the Serotonin Syndrome.
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