Guillermo Rodriguez
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The Prokinetic Effect of Mosapride Citrate on Horse Gastric Emptying Rates
Koichi OKAMURA1), Naoki SASAKI2)*, Morito FUKUNAKA2), Haruo YAMADA2) and Hisashi INOKUMA2)
ABSTRACT. The prokinetic effect of the 5-HT4 receptor agonist mosapride was evaluated in seven healthy thoroughbreds. Mosapride was
orally administerd at doses of 0.5, 1.0 or 1.5 mg/kg. The breath 13CO2/12CO2 rate (Δ13CO2), an indirect indicator for the rate of gastric
empting, was measured at appropriate points for 4 hr after drug administration. There was a significant increase compared with the control
value at 15, 20 and 165 min for 0.5 mg/kg, 30 min at 1.0 mg/kg and 165 min for 1.5 mg/kg. The results suggest that mosapride
may facilitate the gastric emptying in horses.
KEY WORDS: equine, gastric emptying rate, mosapride citrate.
J. Vet. Med. Sci. 70(6): 627–628, 2008
http://www.mediafire.com/?79jnxn8s2a8n1w9
Koichi OKAMURA1), Naoki SASAKI2)*, Morito FUKUNAKA2), Haruo YAMADA2) and Hisashi INOKUMA2)
ABSTRACT. The prokinetic effect of the 5-HT4 receptor agonist mosapride was evaluated in seven healthy thoroughbreds. Mosapride was
orally administerd at doses of 0.5, 1.0 or 1.5 mg/kg. The breath 13CO2/12CO2 rate (Δ13CO2), an indirect indicator for the rate of gastric
empting, was measured at appropriate points for 4 hr after drug administration. There was a significant increase compared with the control
value at 15, 20 and 165 min for 0.5 mg/kg, 30 min at 1.0 mg/kg and 165 min for 1.5 mg/kg. The results suggest that mosapride
may facilitate the gastric emptying in horses.
KEY WORDS: equine, gastric emptying rate, mosapride citrate.
J. Vet. Med. Sci. 70(6): 627–628, 2008
http://www.mediafire.com/?79jnxn8s2a8n1w9