Endocrine-Disrupting Chemicals An Endocrine

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Iraq Professor at Vet School
Endocrine-Disrupting Chemicals An Endocrine
Diamanti-Kandarakis E et al.

View attachment 2268
[FONT=&quot]Pages:[/FONT][FONT=&quot]56
Publisher:The Endocrine Society
Edition:2009
Language: English
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[FONT=&quot] [/FONT]
Description
[FONT=&quot] An endocrine-disrupting compound was defined by the
U.S. Environmental Protection Agency (EPA) as “an
exogenous agent that interferes with synthesis, secretion,
transport, metabolism, binding action, or elimination of
natural blood-borne hormones that are present in the
body and are responsible for homeostasis, reproduction,
and developmental process.” Our understanding of the
mechanisms by which endocrine disruptors exert their effect
has grown. Endocrine-disrupting chemicals (EDCs)
were originally thought to exert actions primarily through
nuclear hormone receptors, including estrogen receptors
(ERs), androgen receptors (ARs), progesterone receptors,
thyroid receptors (TRs), and retinoid receptors, among
others.[/FONT]

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