The Effect of Lidocaine on Postoperative Jejunal Motility in Normal Horses

[Guillermo Rodriguez]

The Effect of Lidocaine on Postoperative Jejunal Motility in
Normal Horses

MELISSA MILLIGAN, DVM, MS, WARREN BEARD, DVM, MS, Diplomate ACVS,
BUTCH KUKANICH, DVM, PhD, Diplomate ACVCP, TIM SOBERING, MS, and SARAH WAXMAN, BS



Veterinary Surgery
36:214–220, 2007

Objective—To measure the effect of lidocaine on the duration of the migrating myoelectric complex
(MMC) and Phases I, II, and III of theMMC, spiking activity of the jejunum, and number of Phase
III events when administered postoperatively to normal horses.
Study Design—Nonrandomized cross-over design.
Methods—Horses were anesthetized and via flank laparotomy 4 silver–silver chloride bipolar electrodes
were sutured to the proximal jejunum. Electrical activity was recorded for 6 hours during
3 recording sessions beginning 24, 48, and 72 hours postoperatively. Saline (0.9% NaCl) solution
was administered for 3 hours followed by lidocaine administration for 3 hours (1.3mg/kg bolus
intravenously [IV], 0.05mg/kg/min IV constant rate infusion).
Results—Duration of MMC was unchanged during lidocaine administration (77 minutes—saline
versus 105 minutes—lidocaine, P¼.16). Durations of Phase I and II were unchanged during
lidocaine administration (P¼.19 and .056, respectively). Phase III was shorter during lidocaine
administration (P¼.002). Spiking activity was unchanged at all time periods during lidocaine
administration (24 hours—P¼.10; 48 hours—P¼.95; and 72 hours—P¼.12). The number of
Phase III events was unchanged over all time periods during lidocaine administration (P¼.053).
Conclusions—Duration of MMC, spiking activity, and number of Phase III events was unchanged
during lidocaine administration.
Clinical Relevance—Use of lidocaine as a prokinetic agent cannot be supported by this study in
normal horses; however, results may differ in clinically affected horses.

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